Cuprident Toothpaste - Natural, Non-Toxic, No Fluoride, Reduces Plaque    

Trial Title: Evaluating the Anti-Plaque Capabilities of a Copper - Containing Prophylaxis Paste

Author:  R. L. Moore, S. M. Feldman, L. J. Abbott, C. J. Reed, J. N. Williams, and J. W.              Wittwer Department of Periodontics, School of Dentistry, University of Louisville.

The purpose of this study was to evaluate a dental prophylaxis paste containing mono-copper citrate (MCC®) for short term anti-plaque capabilities. In addition to other baseline data, plaque scores were recorded on 36 paid volunteer subjects from the dental school student, staff, and faculty populations. After scaling, two quadrants of each subject’s dentition were polished with the MCC® containing paste and two quadrants with the placebo paste, using a diagonal split mouth double blind design. Subjects did not brush or floss for two days. Plaque scores were recorded at 24 and 48 hours, after which they resumed normal hygiene.


Results showed that after 24 hours placebo areas had 92% higher plaque and after 48 hours 33% higher plaque than the active paste areas. This was statistically significant at the P < .001 level. The diminishing effect of the copper containing prophy paste over 48 hours might indicate that the copper ion should be applied on a daily basis for best anti-plaque results.

See Full Text

The following graphical representation of test results summarizes the Clinical Data collected in the course of two separate clinical trials of four dentifrice products:

Clinical Efficacy Studies of Four Dentifrice Products in the Treatment of Gingivitis, Gingival Bleeding and Plaque

CUPRIDENT™ PROFESSIONAL FORMULA DENTIFRICE

	This Graphical Presentation Format presents with clarity the superior performance of the Cuprident Professional Formula Dentifrice product in all categories evaluated. BRAND "A" REGULAR FLUORIDE TOOTHPASTE BRAND "B" HERBAL TOOTHPASTE BRAND "C" TARTAR CONTROL TOOTHPASTE See Full Text

Study Overview 2

Trial Title: Therapeutic Effects on Gingival Health of Mono Copper (II) Citrate In Toothpaste.

Author: R.L.Moore, M. Hill, L.J. Abbott, J.W. Wittwer, J.N. Williams, M. Gleason School of Dentistry,            University of Louisville


The purpose of this study was to document the effects on gingival and sulcular health, and plaque and calculus formation by a toothpaste containing Disodium Monocopper Citrate (MCC®).

The study utilized two groups of paid volunteers; test groups and control groups were formed. This study was performed over a 12 week period in double-blind fashion where neither subjects nor examiners knew which toothpaste was which. At the end of the 12 weeks, it appeared that MCC® applied to the teeth on a daily basis as a toothpaste has therapeutic effect of increased gingival health, decreased accumulation of plaque, and reduced bleeding on probing.

See Full Text See Abstract

Study Overview 3

Title: Some Suggested Relationships of Copper and Inflammation

Author: National Research Laboratories

·Strict anaerobes do not survive in an oxidizing environment.

· Adsorption of MCC® to bacterial and other surfaces may sterically hinder hydrogen/electrostatic bonding to surfaces resulting in changes in adherence properties.

· Neutralization of odiferous substances is accomplished by the reactions with MCC®.

· Bacteria per se do not directly attack oral tissues; moieties associated with bacteria—metabolites, exoenzymes – are the immediate causes of tissue destruction. If the offending metabolite or enzyme fails in its attempt to react with a substrate, the substrate will be spared.

See Full Text